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The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier

granatum on the attenuation of oxidative stress indices

19 This can increase susceptibility of intestinal permeability (leaky gut), allowing harmful substances to enter the bloodstream and trigger systemic inflammation

2021;54:e13134

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SGLT2 inhibitors are anti-hyperglycemic drugs that have been applied to treat diabetes [223], as well as other metabolic disorders such as CVD and renal dysfunction [224]