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The TGF-/SMAD pathway is critical in regulating fibroblast activity, promoting extracellular matrix deposition by upregulating the production of collagen, fibronectin, and proteoglycans

PLoS Pathog 6:e1000902

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Nevertheless, other randomized clinical trials failed to demonstrate any beneficial effect of selenium supplementation in GD (81, 82) or in HT [79, 80]