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doi: 10.4161/onci.21176 80 CarlinoFDianaAPiccoloAVentrigliaABrunoVDe SantoIet al

Appropriate treatment and preventative methods play an effective role in minimizing this problem

324 mTORC1 also promotes purine synthesis via the transcription factors ATF4, MYC and FOXK1, 177,299 which control a variety of metabolic enzymes that contribute to purine biosynthesis