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"By the time symptoms appear, the disease may already be advanced." Symptoms are "especially worrisome" for those 45 and older who have at least one first-degree relative with colon cancer or other GI malignancies, and those with active inflammatory bowel disease, such as ulcerative colitis or Crohns disease, added Friedman, who is also an advisory board member at SpotitEarly, a startup that offers an at-home breath test to detect early-stage cancer signals