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Serum ACE1 and ACE2 levels and the ACE1/ACE2 ratio are associated with several comorbidities that can worsen COVID-19 severity, including hypertension, type II diabetes, obesity and cardiovascular disease, and in those who smoke 14

In addition to cytochrome c, ribonuclease A (RNase A, with the size of 2.2 * 2.8 * 3.8 nm) is also widely used as a protein drug model to test the delivery efficacy and the intracellular functions

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