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The potential role of pharmacogenomics in the prevention of serious adverse drug reactions in multiple sclerosis

Given that an increase, but not a decrease, in the Kyn/Trp ratio is expected to be associated with inflammation, and that we observe a one-directional trend towards increased values among the asymptomatic V30M carriers compared to controls (Table 2

Frequency varies depending on the clinical reason and individual needs

Similarly, finding from other studies demonstrated the ability of the autophagy activator, metformin to attenuate CP-induced ototoxicity, cardiotoxicity, and neurotoxicity primarily through AMPK activation (Guo et al., 2021