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This difference in signaling modalities may be responsible to the significant reduction in the number of spikes in bursts we observe, even in cultures exposed to low concentrations of IL-6

However, when oxidative stress surpasses their regulatory capacity, astrocytes transition into a reactive state, leading to excessive ROS production and neuroinflammation

doi: 10.1111/1541-4337.12898 41 LongYZhangMMujumdarASChenJ

It is believed that inflammatory and oxidative damage in the brain contribute to the progression of AD