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Interrupting glycolysis is highly valued as a therapeutic strategy, because glycolytic disruption is generally tolerated in mammals

But people should be cautious about taking supplements in general, particularly glutathione

Importantly, glutathione (GSH) acts as an essential cofactor for the enzyme family glutathione peroxidases (GPx), which catalyze the reduction of hydrogen peroxide and lipid hydroperoxides into water and their corresponding alcohols

Domestic Anim Endocrinol 23(12):3342 Niisato N, Marunaka Y (2023) Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus

KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma

GSH is found predominantly in the cytosol (~90%), with smaller but vital pools in mitochondria and the endoplasmic reticulum