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Sleep deprivation and aging are known to upregulate histone deacetylases, which remove acetyl groups from histone proteins, leading to chromatin condensation and suppressed expression of genes critical for long-term potentiation and synaptic plasticity (Wong et al., 2020)

Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence

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This proposal was supported subsequently by other scientists by 1930

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The N-terminal domain was exposed to the solvent, whereas the C-terminal helix, called the helical thong, was inserted into a hydrophobic hole in the opposite subunit of the other hexameric ring (Fig