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In addition to using genetically engineered bacteria as drug delivery carriers, extracellular vesicles (EVs), especially exocrine bodies, originate from cells through exocytosis and are absorbed by target cells, which can transmit biological signals or even deliver drugs between local or distant cells (47)

Mitchell KG, Diao L, Karpinets T, Negrao MV, Tran HT, Parra ER, Corsini EM, Reuben A, Federico L, Bernatchez C, Dejima H, Francisco-Cruz A, Wang J, Antonoff MB , Vaporciyan AA, Swisher SG, Cascone T, Wistuba II, Heymach JV, Gibbons DL, Zhang J, Haymaker CL, Sepesi B

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PMID: 11713470 Editor information Editors and Affiliations Rights and permissions Copyright information 2022 Springer Nature Switzerland AG About this entry Cite this entry Rizzo, F.R., Bruno, A., Federici, M., Mercuri, N.B

The treatment is very low risk because it uses the animals own stem cells

[DOI] [PubMed] [Google Scholar] 174.Doaa M.Y., Rabab M.E., Dina M.S., Eman M.E