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doi: 10.1016/S2215-0366(15)00309-0 95 GillJVythilingamMPageGG

doi: 10.1093/nar/gkaa1024 30 BjrkARichardsdotter AnderssonEImgenberg-KreuzJThorlaciusGEMoforsJSyvnenACet al

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Combined cistromic and transcriptomic analyses have shown that AR expressed in myofibers controls the expression of transcription factors and genes involved in glycolysis, fatty acid metabolism, polyamine biosynthesis, reactive oxygen species (ROS) scavenging and cytoskeleton remodeling of skeletal muscle

Whats happening: Weeks of elevated GH are now producing measurable body-composition change, more lean mass, less fat mass

It binds directly to IGF-1 receptors in muscle, bone, and adipose tissue, initiating anabolic cascades independent of upstream hormonal regulation