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For example, a compact structure may make the binding of GH receptors to GH in ice age animals more stable, which is beneficial for more effective utilization of growth hormone to regulate metabolic processes in low food resource environments

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The original Cell Metabolism discovery paper established that MOTS-c regulates insulin sensitivity through this pathway, and later work in Nature Communications by Reynolds et al

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Key takeaways for peptide research include: Animal success human efficacy: Lipid-metabolism regulation in rodents differs markedly from humans

The further roles of NNMT in regulating glucose metabolism and the related mechanisms are mainly from Kraus et al