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doi: 10.1126/science.abh2444 38 HanahanDWeinbergRA

Berberine treatment-emergent mild diarrhea associated with gut microbiota dysbiosis

Role of catalase in oxidative stress- and age-associated degenerative diseases

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This activation triggers the NF-B signaling cascade, leading to a transcriptional upregulation of pro-inflammatory cytokines (e.g., TNF-, IL-1, IL-6), chemokines, and adhesion molecules, which in turn recruit more immune cells to the injury site, and driving chronic inflammation and tissue damage (85)

Science 301, 13741377.10.1126/science.1086907 131 WedemayerG