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The treated groups exhibited an average improvement in this ratio of +55.1% (supplement), +39.4% (lotion), and +63.5% (combination), whereas the control group experienced a slight decrease of 3.9%

A Wilcoxon rank-sum test was performed to compare HRQoL scores between subgroups

Subjects were excluded for the following reasons: creatine or L-arginine use within 1 month, myocardial infarction or intervention within 2 weeks, or change in medication within 1 week

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Sections of the corpus callosum were washed in cacodylate buffer and post-fixed with 1%osmiumtetroxide/1.5% potassiumferrocyanide (in H 2 O) for 1 h at RT