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coli and the presence of intrinsically disordered regions (Supplementary Fig

In rat esophagitis and failed function of both lower esophageal sphincter (LES) and pyloric sphincters (PS), BPC 157 increased pressure in both sphincters till normal and reduced esophagitis

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5 Therapeutic potential of IGF-1-R targeting in cancer 5.1 IGF-1R silencing can abrogate cancer drug resistance in vitro It appears from the data presented above that IGF-1-R signaling targeting could be an excellent therapeutic strategy in cancer, particularly in chemotherapy resistant cases ( Figure 4 )